Tomyris was a queen of the Massagetae (c. 530 BC). After she found out about the death of her son, Spargapises, at the hands of Cyrus the Great she led the Massagetean army into war, and, during the battle defeated the Persians and destroyed most of their army.
Queen Adad-Guppi was the daughter of King Ashurbanipal II and Ashursharrat l… and mother to King Nabonidus. It’s been suggested that she acted as a regent for Nabonidus when he abandoned Babylon in 552 BC for Tema. The Tema Stele (c. 6 century BC), represent an important part of the history of Tema and of the history of the Arabian Peninsula.
Šērūʾa-ēṭirat was the eldest daughter of Assyrian King Esarhaddon (r. 681 to 669 BC) and the older sister of twins, Ashurbanipal and Šamaš-šuma-ukin, crown princes of Assyria and of Babylonia. She was likely involved in politics.
Queen Naqiya-Zakutu was the wife of King Sennacherib, mother of King Esarhaddon, and grandmother of Ashurbanipal of Assyria's final ruling dynasty, the Sargonid Dynasty.
Queen Sammu-Ramat was the wife and queen of King Shamshi-Adad V (r. 824–811 BC), a son and successor of King Shalmaneser III. Around 806 BC, her son, King Adad-Nirari III was at an age where he could take on the full responsibility of the Assyrian throne.