Metal hypersensitivity is one of the most common types of skin allergies. It's attributed to nickel which is used in many of our everyday items such as jewelry, coins, or cell phones.
The Bronze Age is a prehistoric period dated to approximately 3300 BC to 1200 BC. It arose following the Chalcolithic period, in which early metals of copper and gold were crafted, as well as the first alloys of copper and tin, from which bronze is derived.
Pearls, are known as the Queen of Gems, are a mollusk's response to an irritant. The "invading body" is generally organic, and the mollusk — oyster, mussel, conch — seeks to lessen the irritation and coats the foreign body with a fluid, which in turn results in a pearl.
Throughout history, beads have been used for spiritual/devotional purposes, as worry beads, gaming beads, for medicinal purposes, and as a form of currency. They're considered to be one of the oldest forms of trade.